Built with versatility in mind, the TripleTOF technology unleashes sensitivity, speed, and productivity in a single multifaceted platform to help you dig deeper into complex samples. Ultra-fast acquisition rates allow you to collect high-resolution MS/MS data on every detectable analyte in your sample, giving you the potential you need to advance your research.
Power Your Workflows with High-Resolution Accurate Mass LC-MS
- Fast acquisition speed with no compromise in data resolution to identify more compounds in your sample
- More complete data-with high-resolution MS/MS data on every detectable analyte
- Advanced workflow capabilities – with high-performance sensitivity
- Enhanced quantitation- with extended linear dynamic range
High Resolution Accurate Mass Spec Technology
Taking Mass Spec Analysis to the Edge
With more ions produced, better ion focusing, improved ion reflection and maximized detection, you will experience the performance edge with the TripleTOF 6600 system. Optimized instrument control electronics in conjunction with patented LINAC collision cell technology delivers ultra-fast acquisition rates of up to 100 MS/MS per cycle for IDA mode and 200 MS/MS per cycle for SWATH® data-independent acquisition, without compromising resolution.
IonDrive™ Turbo V Source
The new design of the legendary Turbo V source increases ion production by using enhanced gas flow dynamics and optimized heater configuration to improve reliability, reproducibility, and robustness at higher flow rates.
QJet® Ion Guide
Designed for robustness, the QJet Ion guide provides large capture radius for efficient transfer of ions from source to quadrupole optics.
High Frequency LINAC® Collision Cell
High drive frequency collision cell provides better ion transmission, higher duty cycle, and improved resolution by focusing ions prior to entering TOF.
Accelerator TOF™ Analyzer
Time-of-flight analyzer uses a 2-stage mirror and 15 kV acceleration to improve resolution and efficiency. Get the speed and sensitivity required for triple quadrupole like quantitation, but with high resolution and mass accuracy for qualitative applications.
Detection System
4-channel MCP detector with ADC processing technology provide more than 5-orders of linear dynamic range while improving robustness and lifetime at high ion currents.
| Key Features |
|
| Mass Range TOF |
5 – 40,000 m/z |
| Mass Selection Range Q1 |
5 – 2250 m/z |
| TOF-MS Mass Resolution and Acquisition Speed |
=35,000 (FWHM) at 956 m/z, using 10 ms accumulation time |
| TOF-MS/MS Mass Resolution and Acquisition Speed |
=30,000 (FWHM) at 813 m/z, and =25,000 (FWHM) at 195 m/z, using 10 ms accumulation time |
| Detector Type |
4-channel MCP detector with ADC signal processing for extended dynamic range |
| Flexible Data Acquisition Workflows |
TOF-MS
Information dependent acquisition (IDA) MS/MS
Data Independent SWATH® Acquisition with fixed or variable Q1 isolation windows
Targeted MRMHR workflow |
| Ionization Sources |
IonDrive™ Turbo V, DuoSpray™ source, each with TurboIonSpray® or Atmospheric-pressure chemical ionization (APCI) probes available; NanoSpray® III source, Digital PicoView NanoSource |
| Orthogonal Front End Separation Compatibility |
Compatible with advanced front-end separation strategies including high-flow, microflow and nanoflow chromatography, capillary electrophoresis spray ionization (CESI), or using SelexION® differential ion mobility |
| Variable Window SWATH® Acquisition |
Data-Independent SWATH® Acquisition with variable window capabilities, allows for a large number of Q1 isolation windows at user controlled widths, up to 200 per cycle to achieve better specificity, even in complex samples. Read More |
| Data File Portability |
Condensed data file sizes simplify and streamline data storage and portability for sharing with colleagues, without losses in data quality, completeness or security |
Workflows Powered by the TripleTOF 6600 System
Introducing the Multi-Omics Powerhouse
Analyze your complex samples faster without compromising between speed, resolution and sensitivity. Identify and quantify your sample components more comprehensively across a broad dynamic range of concentrations with the high-resolution MS/MS, at ultra-fast acquisition speeds.
The Optimal Choice for Comprehensive Pharma/BioPharma Analysis
From qualitative characterization experiments to high quality quantitation, this system gives you the power, sensitivity and flexibility to support and advance your therapeutic discovery and development pipeline.
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