eDAQ | TethaPatch | SDx-R2 for sale from eDAQ

eDAQ | TethaPatch | SDx-R2

Supplier: eDAQ

eDAQ | TethaPatch | SDx-R2

The TethaPatch™ SDx-R2 is designed for use with a TethaPlate™ for patch-clamp style experiments with ER466 Potentiostat system on tethered membrane preparations.

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The tethaPatch™ six separate chambers of the tethaPlate can be addressed individually for convenient replicate experiments, or separate experiments can be performed in each chamber.

Features & Functions

By assembling a single type of ion channel protein in a large patch (2.1 mm² area) of artificial tethered membrane somewhere between 1 and 10 million channels can be studied in parallel.
The measured ion current is the sum total from all the ion channels in the patch so that signals in the microampere ranges are obtained with concomitantly low noise levels.
The ion channels spontaneously house themselves in the tethered membrane which is already bonded to the working electrode. There is no 'hit-or-miss' approach with a micropipette electrode.

Benefits

TethaPatch™ techniques, typically provide results in minutes that would otherwise take hours with conventional techniques.
Tethered membranes are very robust, voltage pulses can be applied that would otherwise 'blow' the seal of a traditional patch clamp preparation. Thus voltage-gated, and mechanosensitive ion channels can now be studied over a wide range of pulse amplitudes (potentials between -500 to +800 mV can be applied) than previously achievable (typically less than ±300 mV), leading to new insights into the mechanism of ion channel behaviour.

The ER466 Integrated Potentiostat is suitable for use with the tethaPatch for pulse generation and data acquisition of the current signal.

To contact eDAQ about eDAQ | TethaPatch | SDx-R2 use Get a quote.

The tethaPatch™ six separate chambers of the tethaPlate can be addressed individually for convenient replicate experiments, or separate experiments can be performed in each chamber.

Features & Functions

By assembling a single type of ion channel protein in a large patch (2.1 mm² area) of artificial tethered membrane somewhere between 1 and 10 million channels can be studied in parallel.
The measured ion current is the sum total from all the ion channels in the patch so that signals in the microampere ranges are obtained with concomitantly low noise levels.
The ion channels spontaneously house themselves in the tethered membrane which is already bonded to the working electrode. There is no 'hit-or-miss' approach with a micropipette electrode.

Benefits

TethaPatch™ techniques, typically provide results in minutes that would otherwise take hours with conventional techniques.
Tethered membranes are very robust, voltage pulses can be applied that would otherwise 'blow' the seal of a traditional patch clamp preparation. Thus voltage-gated, and mechanosensitive ion channels can now be studied over a wide range of pulse amplitudes (potentials between -500 to +800 mV can be applied) than previously achievable (typically less than ±300 mV), leading to new insights into the mechanism of ion channel behaviour.

The ER466 Integrated Potentiostat is suitable for use with the tethaPatch for pulse generation and data acquisition of the current signal.

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To contact eDAQ about eDAQ | TethaPatch | SDx-R2 use Get a quote.